[1] Spike protein on the virion binds to ACE2, a cell-surface protein. TMPRSS2, an enzyme, helps the virion enter [2] The virion releases its RNA [3] Some RNA is translated into proteins by the cell’s machinery [4] Some of these proteins form a replication complex to make more RNA [5] Proteins and RNA are assembled into a new virion in the Golgi and [6] released. Sources: Song et al., ‘Viruses’, 2019; Jiang et al., ‘Emerging Microbes and Infections, 2012; ‘The Economist’.
" If we understand How It Works then we can build a vacine strategy around possible interventions such as entry accross the membrane or inhibit its replication For example if an anitobody inhibits the receptor on the Virus surface to stop it enterring a cell and allowing multiplication"
The disease may complicate trasmission as patients may be either
Symptomatic OR Unsymptomatic
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